Un giro en la Biología: explorando los ARNs circulares y su impacto
DOI:
https://doi.org/10.29105/cienciauanl27.124-3Keywords:
ARN, ADN, ARN circulares, genoma, genómicaAbstract
En la actualidad, el ARN por definición es una molécula de cadena sencilla presente en todas las células vivas. Dicha molécula, de gran relevancia biológica y multifacética, juega un papel central y moderador en la expresión génica. Traduce los mensajes contenidos en los genes del ácido desoxirribonucleico (ADN), lo que lleva a la síntesis de las proteínas esenciales en el funcionamiento celular.
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References
Bai, Y., et al. (2022). Research Progress on Circular RNA Vaccines. Frontiers in Immunology, 13, 1091797. DOI: https://doi.org/10.3389/fimmu.2022.1091797
Caba, L., et al. (2021). Circular RNA-Is the Circle Perfect? Biomolecules, 11(12). DOI: https://doi.org/10.3390/biom11121755
Chen, N., et al. (2018). A Novel FLI1 Exonic Circular RNA Promotes Metastasis in Breast Cancer by Coordinately Regulating TET1 and DNMT1. Genome Biology, 19(1), 218. DOI: https://doi.org/10.1186/s13059-018-1594-y
Du, W.W., et al. (2018). A Circular RNA circ-DNMT1 Enhances Breast Cancer Progression by Activating Autophagy. Oncogene, 37(44), 5829-5842. DOI: https://doi.org/10.1038/s41388-018-0369-y
Garber, K. (2022). Orna Therapeutics: Circular Logic. Nature Biotechnology [Preprint]. DOI: https://doi.org/10.1038/d41587-022-00005-1
He, A.T., et al. (2021). Targeting Circular RNAs as a Therapeutic Approach: Current Strategies and Challenges. Signal Transduction and Targeted Therapy, 6(1), 185. DOI: https://doi.org/10.1038/s41392-021-00569-5
Li, J., et al. (2020). Circular RNAs in Cancer: Biogenesis, Function, and Clinical Significance. Trends in Cancer Research, 6(4), 319-336. DOI: https://doi.org/10.1016/j.trecan.2020.01.012
Li, L. et al. (2019). FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 25(4), 1302-1317. DOI: https://doi.org/10.1158/1078-0432.CCR-18-1447
Li, X., Yang, L., y Chen, L.-L. (2018). The Biogenesis, Functions, and Challenges of Circular RNAs. Molecular Cell, 71(3), 428-442. DOI: https://doi.org/10.1016/j.molcel.2018.06.034
Luo, Y.-H., et al. (2020). Plasma Level of Circular RNA hsa_circ_0000190 Correlates with Tumor Progression and Poor Treatment Response in Advanced Lung Cancers. Cancers, 12(7). DOI: https://doi.org/10.3390/cancers12071740
News & Media. (2020). Orna Therapeutics. https://www.ornatx.com/news-and-media/?pag=1&category=21
Qu, L., et al. (2022). Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants. Cell, 185(10), 1728-1744.e16. DOI: https://doi.org/10.1016/j.cell.2022.03.044
Zheng, Q., et al. (2016). Circular RNA Profiling Reveals an Abundant circHIPK3 That Regulates Cell Growth by Sponging Multiple miRNAs. Nature Communications, 7, 11215. DOI: https://doi.org/10.1038/ncomms11215
Zhong, L., et al. (2021). Circulating CircRNAs Panel Acts as a Biomarker for the Early Diagnosis and Severity of Parkinson’s Disease. Frontiers in Aging Neuroscience, 13, 684289. DOI: https://doi.org/10.3389/fnagi.2021.684289
