Nanopartículas en protección solar infantil y pieles sensibles: ¿Riesgo real o mito moderno?
Nanoparticles in sunscreens for children and sensitive skin: real risk or modern myth?
DOI:
https://doi.org/10.29105/cienciauanl29.138-2Palabras clave:
nanopartículas, fotoprotección, piel, radiación UV, seguridad., nanoparticles, photoprotection, skin, UV radiation, safetyResumen
La piel es la primera barrera del cuerpo frente a la radiación ultravioleta, cuya exposición excesiva puede causar envejecimiento prematuro y cáncer; en niños, este riesgo aumenta, haciendo esencial usar protectores solares, prefiriendo aquellos con filtros inorgánicos. Actualmente, las nanopartículas de óxido de zinc representan una alternativa eficaz, ya que ofrecen una defensa alta sin dejar residuos visibles, no obstante, su uso ha generado inquietudes respecto a la posible absorción, efectos a nivel celular y seguridad. Diversos estudios confirman que no penetran capas profundas cutáneas ni generan toxicidad, consolidándose como una opción para proteger la piel infantil y sensible.
Abstract
Skin constitutes the primary barrier of the human body against ultraviolet radiation, whose excessive exposure may cause premature aging and cancer. In children, this risk is higher, making sunscreens usage essential, preferably those containing inorganic filters. Zinc oxide nanoparticles currently represent an effective alternative, as they provide high protection without leaving visible residues on the skin. However, their use has raised concerns regarding potential absorption, cellular effects, and safety. Several studies confirm that these nanoparticles do not penetrate the deeper layers of the skin or cause toxicity, establishing them as a suitable option for protecting sensitive and pediatric skin.
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Cox, Neil, Diffey, Brian, Farr, Peter. (1992). The relationship between chronological age and the erythemal response to ultraviolet B radiation, The British journal of dermatology, 126(4), 315-319. DOI: https://doi.org/10.1111/j.1365-2133.1992.tb00671.x
Gilaberte, Yolanda, Carrascosa, José M. (2014). Realidades y retos de la fotoprotección en la infancia, Actas Dermo-Sifiliográficas, 105(3), 253-262. DOI: https://doi.org/10.1016/j.ad.2013.05.004
Gulson, Brian, McCall, Maxine, Korsch, Michael, et al. (2010). Small amounts of zinc from zinc oxide particles in sunscreens applied outdoors are absorbed through human skin, Toxicological Sciences, 118(1), 140-149. DOI: https://doi.org/10.1093/toxsci/kfq243
Hashempour, Sara, Ghanbarzadeh, Saeed, Maibach, Howard, et al. (2019). Skin toxicity of topically applied nanoparticles, Therapeutic delivery, 10(6), 383-396, https://doi.org/10.4155/tde-2018-0060 DOI: https://doi.org/10.4155/tde-2018-0060
Hegde, Aswathi R., Kunder, Manisha U., Narayanaswamy, M., et al. (2024). Advancements in sunscreen formulations: integrating polyphenolic nanocarriers and nanotechnology for enhanced UV protection, Environ Sci Pollut Res, 31, 38061-38082, https://doi.org/10.1007/s11356-024-33712-0 DOI: https://doi.org/10.1007/s11356-024-33712-0
Irede, Egwonor L., Awoyemi, Raymond F., Owolabi, Babatunde, et al. (2024). Cutting-edge developments in zinc oxide nanoparticles: synthesis and applications for enhanced antimicrobial and UV protection in healthcare solutions, RSC Advances, 14(29), 20992-21034. DOI: https://doi.org/10.1039/D4RA02452D
Jung, Katinka, Seifert, Marietta, Herrling, Thomas, et al. (2008). UV-generated free radicals (FR) in skin: their prevention by sunscreens and their induction by self-tanning agents, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 69(5), 1423-1428.
Leite-Silva, Vânia R., Le Lamer, Marina, Sánchez, Washington Y., et al. (2013). The effect of formulation on the penetration of coated and uncoated zinc oxide nanoparticles into the viable epidermis of human skin in vivo, European Journal of Pharmaceutics and Biopharmaceutics, 84(2), 297-308. DOI: https://doi.org/10.1016/j.ejpb.2013.01.020
Liang, Xiao W., Xu, Zhi P., Grice, Jeffrey, et al. (2013). Penetration of nanoparticles into human skin, Current Pharmaceutical Design, 19(35), 6353-6366. DOI: https://doi.org/10.2174/1381612811319350011
Lin, Lynlee L., Grice, Jeffrey E., Butler, Margaret K., et al. (2011). Time-correlated single photon counting for simultaneous monitoring of zinc oxide nanoparticles and NAD(P)H in intact and barrier-disrupted volunteer skin, Pharmaceutical Research, 28(11), 2920-2930. DOI: https://doi.org/10.1007/s11095-011-0515-5
Lyons, Alexis B., Trullas, Carles, Kohli, Indermeet, et al. (2020). Photoprotection beyond ultraviolet radiation: A review of tinted sunscreens, Journal of the American Academy of Dermatology, Advance online publication, https://doi.org/10.1016/j.jaad.2020.04.079 DOI: https://doi.org/10.1016/j.jaad.2020.04.079
Mohammed, Yousuf, Holmes, Amy, Haridass, Isha N., et al. (2019). Support for the safe use of zinc oxide nanoparticle sunscreens: lack of skin penetration or cellular toxicity after repeated application in volunteers, Journal of Investigative Dermatology, 139(2), 308-315. DOI: https://doi.org/10.1016/j.jid.2018.08.024
Nasir, Adnan, Wang, Steven, Friedman, Adam. (2011). The emerging role of nanotechnology in sunscreens: an update, Expert Review of Dermatology, 6(5), 437-439. DOI: https://doi.org/10.1586/edm.11.49
Osmond, Megan, McCall, Maxine. (2010). Zinc oxide nanoparticles in modern sunscreens: an analysis of potential exposure and hazard, Nanotoxicology, 4(1), 15-41. DOI: https://doi.org/10.3109/17435390903502028
Phadungsaksawasdi, Pawit, Sirithanabadeekul, Punyaphat. (2020). Ultraviolet filters in sunscreen products labeled for use in children and for sensitive skin, Pediatric dermatology, 37(4), 632-636. DOI: https://doi.org/10.1111/pde.14170
Pinheiro, Teresa, Pallon, Jan, Alves, L. et al. (2007). The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin, Nuclear Instruments and Methods in Physics Research Section B, 260(1), 119-123. DOI: https://doi.org/10.1016/j.nimb.2007.02.014
Popov, Alexey, Priezzhev, Alexander, Lademann, Jürgen, et al. (2005). TiO₂ nanoparticles as an effective UV-B radiation skin-protective compound in sunscreens, Journal of Physics D: Applied Physics, 38, 2564-2570. DOI: https://doi.org/10.1088/0022-3727/38/15/006
Schneider, Samantha, Lim, Henry. (2019). A review of inorganic UV filters zinc oxide and titanium dioxide, Photodermatology, photoimmunology y photomedicine, 35(6), 442-446, https://doi.org/10.1111/phpp.12439 DOI: https://doi.org/10.1111/phpp.12439
Tanner, Paul. (2006). Sunscreen product formulation, Dermatologic Clinics, 24(1), 53-62. DOI: https://doi.org/10.1016/j.det.2005.09.002
Valdivielso-Ramos, Martha, Mauleón-Fernández, Cristina, Balbín-Carrero, Eva, et al. (2009). Fotoprotección en la infancia, Revista Pediatría de Atención Primaria, 11(42), 313-324. DOI: https://doi.org/10.4321/S1139-76322009000200012
Vieira, Daniela, Duarte, Joana, Vieira, Pedro, et al. (2024). Regulation and safety of cosmetics: pre- and post- market considerations for adverse events and environmental impacts, Cosmetics, 11(6), 184. DOI: https://doi.org/10.3390/cosmetics11060184
Zvyagin, Andrei, Zhao, Xin, Gierden, Audrey, et al. (2008). Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo, Journal of biomedical optics, 13(6), 064031-064031. DOI: https://doi.org/10.1117/1.3041492
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Derechos de autor 2026 Rossie Inelle Meneses-Arguelles, Cesar Uriel Rodriguez Fuentes, Cynthia Cano Sarmiento

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
