Akkermansia muciniphila: de bacteria desconocida a probiótico prometedor
Akkermansia muciniphila: from an unknown bacterium to a promising probiotic
DOI:
https://doi.org/10.29105/cienciauanl29.136-4Palabras clave:
Akkermansia muciniphila, microbiota intestinal, probióticos, obesidad, metabolismo , Akkermansia muciniphila, gut microbiota, probiotics, obesity, metabolism.Resumen
Akkermansia muciniphila es una bacteria residente del tracto gastrointestinal. Desde su descubrimiento, ha despertado interés en la comunidad científica debido a su papel en el metabolismo y la salud humana. Su disminución a nivel intestinal se asocia con enfermedades como la obesidad y la diabetes tipo 2. Se han identificado varios mecanismos a través de los cuales ayuda a mantener el equilibrio del epitelio intestinal. Estudios en animales y en humanos han demostrado que la administración de A. muciniphila se asocia a mejoras en los perfiles bioquímicos y reducción de la inflamación lo que la convierte en un probiótico con gran potencial terapéutico.
Abstract
Akkermansia muciniphila is a resident bacterium of the gastrointestinal tract. Since its discovery, it has attracted considerable interest within the scientific community due to its role in metabolism and human health. Its reduction at the intestinal level is associated with diseases such as obesity and type 2 diabetes. Several mechanisms have been identified throughout which it helps to maintain the balance of the intestinal epithelium. Animal and human studies have shown that the administration of A. muciniphila is associated with improvements in biochemical profiles and reduced inflammation, making it a probiotic with great therapeutic potential.
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Fernandes-Rodrigues, Vanessa, Elias-Oliveira, Jefferson, Sousa-Pereira, Ítalo, et al. (2022). Akkermansia muciniphila and gut immune system: A good friendship that attenuates inflammatory bowel disease, obesity, and diabetes. Frontiers in Immunology, 13, 934695. https://doi.org/10.3389/fimmu.2022.934695 DOI: https://doi.org/10.3389/fimmu.2022.934695
Ma, Junli, Liu, Zekun, Gao, Xinxin, et al. (2023). Gut microbiota remodeling improves natural aging-related disorders through Akkermansia muciniphila and its derived acetic acid. Pharmacological Research, 189, 106687. https://doi.org/10.1016/j.phrs.2023.106687 DOI: https://doi.org/10.1016/j.phrs.2023.106687
Wu, Wenriu, Kaicen, Wang, Bian, Xiaoyuan, et al. (2023). Akkermansia muciniphila alleviates high-fat-diet-related metabolic-associated fatty liver disease by modulating gut microbiota and bile acids. Microbial Biotechnology, 16(10), 1924–1939. https://doi.org/10.1111/1751-7915.14293 DOI: https://doi.org/10.1111/1751-7915.14293
Derrien, Muriel, Vaughan, Elaine E., Plugge, Caroline M., et al. (2004). Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int. Jour. of Syst. and Evol. Mic., 54(5), 1469–1476. https://doi.org/10.1099/ijs.0.02873-0 DOI: https://doi.org/10.1099/ijs.0.02873-0
Karamzin, Andrei M., Ropot, Anastacia V., Sergeyev, Oleg V., et al. (2021). Akkermansia muciniphila and host interaction within the intestinal tract. Anaerobe, 72, 102472. https://doi.org/10.1016/j.anaerobe.2021.102472 DOI: https://doi.org/10.1016/j.anaerobe.2021.102472
Tanes, Ceylan, Bittinger, Kyle, Gao, Yuan, et al. (2021). Role of dietary fiber in the recovery of the human gut microbiome and its metabolome. Cell Host & Microbe, 29(3), 394–407.e5. https://doi.org/10.1016/j.chom.2020.12.012 DOI: https://doi.org/10.1016/j.chom.2020.12.012
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Derechos de autor 2026 Olga Carolina Rojas García, Cintia Amaral Montesino

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
